Can I read Early metabolic changes in peripheral blood cells of renal transplant recipients treated with Cyclosporine A on EtoBox?

Early metabolic changes in peripheral blood cells of renal transplant recipients treated with Cyclosporine A by R Rezzani; L Rodella; R Bianchi is a Immunology and Microbiology article available to read on EtoBox.

What is Early metabolic changes in peripheral blood cells of renal transplant recipients treated with Cyclosporine A about?

We histochemically examined (phosphatase acid-AcP, phosphatase alkaline-ALP, succinate dehydrogenase-SDH, lactate dehydrogenase-LDH) the peripheral blood of renal transplant recipients and controls before (day 0) and after Cyclosporine A (CsA) treatment (days 1, 2, 7 and 30). We wanted to detect the metabolic changes induced in the CsA resistant cells (leucocytes) by CsA and to evaluate the early effects determined by the drug. There was no difference in enzyme activities between the control group and renal patients before CsA treatment (day 0). AcP and ALP activity increased 1 day after CsA administration and became similar to the control by the day 30. LDH activity increased one day after CsA treatment and remained high during the treatment period (30 days), while SDH activity did not change. These enzymatic variations may suggest that the LDH enzyme is involved in the drug degradation as are other phosphatase and oxidoreductase enzymes (i.e. cytochrome P450). Moreover, the high activity of LDH, the enzyme responsible for interconversion of pyruvate in lactic acid, would indicate that anaerobic glycolysis is preferentially used in the pyruvate pathway. However, SDH did not seem t

Who reads Early metabolic changes in peripheral blood cells of renal transplant recipients treated with Cyclosporine A?

Author

R Rezzani; L Rodella; R Bianchi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0192-0561)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)