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Can I read Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation on EtoBox?
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation by B Lutterbach; S.W Hiebert is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation about?
Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia.
Who reads Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- B Lutterbach; S.W Hiebert
- Publisher
- Elsevier BV
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)