Can I read Centriole Polarisation to the Immunological Synapse Directs Secretion from Cytolytic Cells of Both the Innate and Adaptive Immune Systems on EtoBox?
Centriole Polarisation to the Immunological Synapse Directs Secretion from Cytolytic Cells of Both the Innate and Adaptive Immune Systems by Jane C Stinchcombe; Mariolina Salio; Vincenzo Cerundolo; Daniela Pende; Maurizo Arico; Gillian M Griffiths is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Centriole Polarisation to the Immunological Synapse Directs Secretion from Cytolytic Cells of Both the Innate and Adaptive Immune Systems about?
## Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target cell is destroyed. In cytotoxic T lymphocytes (CTLs), this is accomplished by an unusual movement of the centrosome to contact the plasma membrane at the centre of the immunological synapse formed between killer and target cells. Secretory lysosomes are directed towards the centrosome along microtubules and delivered precisely to the point of target cell recognition within the immunological synapse, identified by the centrosome. We asked whether this mechanism of directing secretory lysosome release is unique to CTL or whether natural killer (NK) and invariant NKT (iNKT) cytolytic cells of the innate immune system use a similar mechanism to focus perforin-bearing lysosome release. ## Results NK cells were conjugated with B-cell targets lacking major histocompatibility complex class I 721.221 cells, and iNKT cells were conjugated with glycolipid-pulsed CD1-bearing targets, then prepared for thin-section electron microscopy. High-
Who reads Centriole Polarisation to the Immunological Synapse Directs Secretion from Cytolytic Cells of Both the Innate and Adaptive Immune Systems?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jane C Stinchcombe; Mariolina Salio; Vincenzo Cerundolo; Daniela Pende; Maurizo Arico; Gillian M Griffiths
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 1741-7007)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)