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Can I read Involvement of p38 MAPK/cPLA2 and arachidonic acid metabolic pathway in Shengmai injection-induced pseudo-allergic reactions on EtoBox?
Involvement of p38 MAPK/cPLA2 and arachidonic acid metabolic pathway in Shengmai injection-induced pseudo-allergic reactions by Dunfang Wang; Chen Pan; Jiayin Han; Yong Zhao; Suyan Liu; Chunying Li; Yan Yi; Yushi Zhang; Xuan Tang; Aihua Liang is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Involvement of p38 MAPK/cPLA2 and arachidonic acid metabolic pathway in Shengmai injection-induced pseudo-allergic reactions about?
Ethnopharmacological relevance Adverse reactions to traditional Chinese medicine injections involve pseudo-allergic reactions (PARs). However, in clinical practice, “immediate allergic reactions” and PARs in response to these injections are not often differentiated. Aim of the study This study aimed to clarify the type of reactions produced by Shengmai injections (SMI) and elucidate the possible mechanism. Materials and methods A mouse model was used to evaluate vascular permeability. Metabolomic and arachidonic acid metabolite (AAM) analyses were performed using UPLC-MS/MS, and the p38 MAPK/cPLA2 pathway was detected by western blotting. Results The first exposure to intravenous SMI rapidly and dose-dependently induced edema and exudative reactions in the ears and lungs. These reactions were not IgE-dependent and were likely to be PARs. Metabolomic analysis showed that endogenous substances were perturbed in SMI-treated mice, in which the arachidonic acid (AA) metabolic pathway was the most affected. SMI substantially increased the levels of AAMs in lung, including prostaglandins (PGs), leukotrienes (LTs), and hydroxy-eicosatetraenoic acids (HETEs). The p38 MAPK/cPLA2 signaling pa
Who reads Involvement of p38 MAPK/cPLA2 and arachidonic acid metabolic pathway in Shengmai injection-induced pseudo-allergic reactions?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Dunfang Wang; Chen Pan; Jiayin Han; Yong Zhao; Suyan Liu; Chunying Li; Yan Yi; Yushi Zhang; Xuan Tang; Aihua Liang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)