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High-resolution Liquid Volume Detection in Sub-nanoliter Reactors by Kari T. Hjelt; Richard van den Doel; Wijnand Lubking; Michiel J. Vellekoop is a Engineering article available to read on EtoBox.

What is High-resolution Liquid Volume Detection in Sub-nanoliter Reactors about?

Miniaturized reactors with volumes of 60 and 540 pl with integrated contact-less liquid volume detectors are fabricated on silicon. Aluminum electrodes are fabricated in the bottom of the reactors and covered with silicon nitride for electrical insulation. The reactors are formed in a 6-mm thick SiO layer by dry etching. The liquid volumes in the reactors are determined by using an impedance 2 measurement and compared to the optical fluorescence microscopy measurements for reference. The applicability of the measurement device for different liquid compositions and reactor size is studied. The presented contact-less measuring method can be used to measure sub-nanoliter liquid volumes with a resolution better than 1 pl. The integrated volume measurement method can be employed in Ž . miniaturized automated arrays in High Speed Screening HSS systems to determine the dispensed liquid volume.

Who reads High-resolution Liquid Volume Detection in Sub-nanoliter Reactors?

Author

Kari T. Hjelt; Richard van den Doel; Wijnand Lubking; Michiel J. Vellekoop

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0924-4247)

Published

2000

Language

EN

Field

Engineering (Physical Sciences)