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Additional fibrate treatment in UDCA‐refractory PBC patients by Sung Won Chung; Jeong‐Hoon Lee; Minseok Albert Kim; Galam Leem; Sun Woong Kim; Young Chang; Hyo Young Lee; Jun Sik Yoon; Jun Yong Park; Yun Bin Lee; Eun Ju Cho; Su Jong Yu; Yoon Jun Kim; Jung‐Hwan Yoon is a Medicine article available to read on EtoBox.

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## Abstract ## Background & Aims There is no proven treatment for ursodeoxycholic acid (UDCA)‐refractory primary biliary cholangitis (PBC) other than obeticholic acid. Although fibrates have been reported to improve biochemical parameters, the long‐term effects remain unclear. This study evaluated the effect of fibrate on clinical outcomes of UDCA‐refractory PBC. ## Methods Patients whose alkaline phosphatase (ALP) was not normalized with at least 13 mg/kg of UDCA treatment for >1 year were included from two tertiary referral centres. The primary outcome was ALP normalization. Secondary outcomes included the development of cirrhosis and hepatic deterioration. Immortal time bias was adjusted using the Mantel‐Byar method. ## Results A total of 100 UDCA‐refractory PBC patients were included: 71 patients received UDCA alone (the UDCA group) and 29 patients received UDCA plus additional fibrate treatment of 160 mg/d fenofibrate or 400 mg/d bezafibrate (the fibrate/UDCA group). During the follow‐up period, the probability of ALP normalization was significantly higher in the fibrate/UDCA group (hazard ratio [HR] = 5.00, 95% confidence interval = 2.87‐8.27, __P__ < 0.001). Among 58 non‐cir

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Author

Sung Won Chung; Jeong‐Hoon Lee; Minseok Albert Kim; Galam Leem; Sun Woong Kim; Young Chang; Hyo Young Lee; Jun Sik Yoon; Jun Yong Park; Yun Bin Lee; Eun Ju Cho; Su Jong Yu; Yoon Jun Kim; Jung‐Hwan Yoon

Publisher

Wiley

Published

2019

Language

EN

Field

Medicine (Health Sciences)