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Ultrafast dynamic contrast-enhanced breast MRI: association with pathologic complete response in neoadjuvant treatment of breast cancer by Ji Hee Kim; Vivian Youngjean Park; Hye Jung Shin; Min Jung Kim; Jung Hyun Yoon is a Medicine article available to read on EtoBox.

What is Ultrafast dynamic contrast-enhanced breast MRI: association with pathologic complete response in neoadjuvant treatment of breast cancer about?

## Objectives: The purpose of this study was to investigate whether pretreatment kinetic features from ultrafast dce-mri are associated with pathological complete response (pcr) in patients with invasive breast cancer and according to immunohistochemistry (ihc) subtype. ## Methods: Between august 2018 and june 2019, 256 consecutive breast cancer patients (mean age, 50.2 years; range, 25-86 years) who underwent both ultrafast and conventional dce-mri and surgery following neoadjuvant chemotherapy were included. dce-mri kinetic features were obtained from pretreatment mri data. time-to-enhancement, maximal slope (ms), and volumes at u1 and u2 (u1, time point at which the lesion starts to enhance; u2, subsequent time point after u1) were derived from ultrafast mri. logistic regression analysis was performed to identify factors associated with pcr. ## Results: Overall, 41.4% of all patients achieved pcr. none of the kinetic features was associated with pcr when including all cancers. among ultrafast dce-mri kinetic features, a lower ms (or, 0.982; p = 0.040) was associated with pcr at univariable analysis in hormone receptor (hr)-positive cancers. in triple-negative cancers, a higher v

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Author

Ji Hee Kim; Vivian Youngjean Park; Hye Jung Shin; Min Jung Kim; Jung Hyun Yoon

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)