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**T‐helper 1 dominated responses to erythrocyte Band 3 in NZB mice** by C.‐R. SHEN; G. MAZZA; F. E. PERRY; J. T. BEECH; S. J. THOMPSON; A. CORATO; S. NEWTON; R. N. BARKER; C. J. Elson is a Immunology and Microbiology article available to read on EtoBox.

What is **T‐helper 1 dominated responses to erythrocyte Band 3 in NZB mice** about?

Band 3, the red blood cell (RBC) anion channel protein, is the target autoantigen for the pathogenic RBC autoantibodies and T‐helper (Th) cells in New Zealand Black (NZB) mice with autoimmune haemolytic anaemia (AIHA). To determine the subpopulation of these Th cells, they were stimulated with Band 3 and the profile of the cytokines elaborated by the responding cells was measured. NZB T cells stimulated with Band 3 produced high levels of the Th1 cytokine, interferon‐γ (IFN‐γ), but little or no interleukin‐4 (IL‐4), IL‐5 or IL‐10. Similar patterns were produced by NZB T cells responding to a spectrin preparation from the RBC membrane skeleton, or to mycobacterial heat‐shock protein (hsp) 65 following immunization of mice with hsp 65 in incomplete adjuvant. By contrast, T cells from CBA mice similarly immunized with hsp 65 produced high levels of IL‐4 and IL‐5 in response to hsp 65. Examination of the isotype of the RBC‐bound immunoglobulins in NZB mice revealed that immunoglobulin G2a (IgG2a) autoantibodies were the first to be detected in most mice and that later in the disease, IgG3 autoantibodies were often prominent. It is concluded that, contrary to expectation, the develop

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Author

C.‐R. SHEN; G. MAZZA; F. E. PERRY; J. T. BEECH; S. J. THOMPSON; A. CORATO; S. NEWTON; R. N. BARKER; C. J. Elson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

1996

Language

EN

Field

Immunology and Microbiology (Life Sciences)