About this document
HIPEC: Indications and Rationale by Prasanth Narayanan is a document available to read on EtoBox.
HIPEC involves administering heated chemotherapy drugs into the peritoneal cavity to treat peritoneal surface malignancies. It originated in the 1980s from animal experiments and is usually preceded by cytoreductive surgery. HIPEC provides pharmacokinetic advantages due to the peritoneal-plasma barrier that allows high drug concentrations in the peritoneum with minimal systemic exposure. Hyperthermia and increased membrane permeability from heat further enhance drug absorption and cytotoxic effects. HIPEC i
- Author
- Prasanth Narayanan
- Language
- EN