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Can I read The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles on EtoBox?
The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles by John P. Mogensen; Stanley M. Roberts; Andrew N. Bowler; Christian Thomsen; Lars J.S. Knutsen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles about?
The synthesis and purinergic receptor binding of novel adenosine A, ligands is described. Many selective A, receptor agonists e.g. N-(3-iodobenzyl)adenosine-S-methyluronamide (IB-MECA) contain a 4'ribosylalkylamide moiety. We found that this amide and other F-functional groups could be replaced with an isosteric isoxazole, and the target molecules retained potent binding to the recombinant human A, receptor.
Who reads The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- John P. Mogensen; Stanley M. Roberts; Andrew N. Bowler; Christian Thomsen; Lars J.S. Knutsen
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)