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Transient Expression of Endothelins in the Amoeboid Microglial Cells in the Developing Rat Brain by Chun‐Yun Wu; Charanjit Kaur; Jia Lu; Qiong Cao; Chun‐Hua Guo; Yan Zhou; Viswanathan Sivakumar; Eng‐Ang Ling is a Neuroscience article available to read on EtoBox.
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## Abstract Amoeboid microglial cells (AMC) which transiently exist in the corpus callosum in the postnatal rat brain expressed endothelins (ETs), specifically endothelin‐1 (ET‐1) and ET3 as revealed by real time RT‐PCR. ET immunoreactive AMC occurred in large numbers at birth, but were progressively reduced with age and were undetected in 14 days. In rats subjected to hypoxia exposure, ET immunoexpression in AMC was reduced but the incidence of apoptotic cells was not increased when compared with the control suggesting that this was due to its downregulation that may help regulate the constriction of blood vessels bearing ET‐A receptor. AMC were endowed ET‐B receptor indicating that ET released by the cells may also act via an autocrine manner. In microglia activated by lipopolysaccharide (LPS), ET‐1 mNA expression coupled with that of monocyte chemoattractant protein (MCP‐1) and stromal derived factor‐1 (SDF‐1) was markedly increased; ET‐3 mRNA, however, remained unaffected. AMC exposed to oxygen glucose deprivation (OGD) in vitro resulted in increase in both ET‐1 and ET‐3 mRNA expression. It is suggested that the downregulated ETs expression in vivo of AMC subjected to hypoxia a
Who reads Transient Expression of Endothelins in the Amoeboid Microglial Cells in the Developing Rat Brain?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Chun‐Yun Wu; Charanjit Kaur; Jia Lu; Qiong Cao; Chun‐Hua Guo; Yan Zhou; Viswanathan Sivakumar; Eng‐Ang Ling
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2006
- Language
- EN
- Field
- Neuroscience (Life Sciences)