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Implementation of anti-HDV reflex testing among HBsAg-positive individuals increases testing for hepatitis D by Adriana Palom; Ariadna Rando-Segura; Judit Vico; Beatriz Pacín; Elena Vargas; Ana Barreira-Díaz; Francisco Rodríguez-Frías; Mar Riveiro-Barciela; Rafael Esteban; Maria Buti is a Medicine article available to read on EtoBox.
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## Background & Aims Although EASL guidelines recommend anti-HDV testing in all HBsAg-positive individuals, HDV infection remains an underdiagnosed condition. We describe the impact of an HDV screening program by reflex anti-HDV testing in all HBsAg-positive samples and compare the results before and after its implementation. ## Methods In total, 2,236 HBsAg-positive determinations were included from January 2018 to December 2021. Only the first sample from each participant was evaluated: 1,492 samples before reflex anti-HDV testing (2018–2020) and 744 samples after (2021). Demographic and clinical characteristics of anti-HDV-positive patients were collected. ## Results Before reflex testing, anti-HDV had been tested in 7.6% (114/1492) of HBsAg-positive individuals: 23% (91/390) attended in an academic hospital and only 2% (23/1,102) in primary care centres. After reflex testing was established, 93% (691/744) of HBsAg-positive cases were evaluated for anti-HDV: 91% (533/586) in the academic hospital and 100% (158/158) in primary care. The anti-HDV-positive prevalence was similar before and after reflex testing: 9.6% (11/114) and 8.1% (56/691), respectively. However, the absolute nu
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- Author
- Adriana Palom; Ariadna Rando-Segura; Judit Vico; Beatriz Pacín; Elena Vargas; Ana Barreira-Díaz; Francisco Rodríguez-Frías; Mar Riveiro-Barciela; Rafael Esteban; Maria Buti
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)