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Sustained release of EGF/bFGF growth factors achieved by mussel-inspired core–shell nanofibers with hemostatic and anti-inflammatory effects for promoting wound healing by Chen Wang; Qingxia Zhang; Guige Hou; Chunhua Wang; Huanhuan Yan is a Materials Science article available to read on EtoBox.
What is Sustained release of EGF/bFGF growth factors achieved by mussel-inspired core–shell nanofibers with hemostatic and anti-inflammatory effects for promoting wound healing about?
Developing wound dressings with high-effective antibacterial activity, rapid hemostasis and accelerated wound healing are urgently needed in clinical wound treatment. Herein, in terms of coaxial electrospinning and mussel-inspired chemistry, a multifunctional polydopamine modified core–shell nanofiber membrane loaded with antibacterial quaternary ammonium salt grafted sulfonated chitosan (QAS-SCS) and bioactive EGF/bFGF in the core layer was constructed for hemostasis and promoting wound healing. The coaxial nanofibers exhibited excellent hydrophilicity,thermalstability, and suitable mechanical strengthand stretchability match human skin. The incorporation of QAS-SCS in the coaxial nanofibers led to efficient inherent antibacterialactivity, with bacteria inhibition rate of 95.15 ± 0.77% and 93.63 ± 1.44% against S. aureus and E. coli, respectively. The biocompatibility of nanofibers was studied through hemocompatibility and cell compatibility tests. In mouse full-thickness skin defect model, together with sustained release of dual growth factors (EGF/bFGF) achieved by core–shell structure, the multifunctional nanofibers were revealed to suppress the release of inflammatory cytokine
Who reads Sustained release of EGF/bFGF growth factors achieved by mussel-inspired core–shell nanofibers with hemostatic and anti-inflammatory effects for promoting wound healing?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Chen Wang; Qingxia Zhang; Guige Hou; Chunhua Wang; Huanhuan Yan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)
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