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Can I read Determination of Impurities in Dextropropoxyphene Hydrochloride by High-performance Liquid Chromatography on Dynamically Modified Silica on EtoBox?
Determination of Impurities in Dextropropoxyphene Hydrochloride by High-performance Liquid Chromatography on Dynamically Modified Silica by Sonja Kryger; Per Helboe is a Chemistry article available to read on EtoBox.
What is Determination of Impurities in Dextropropoxyphene Hydrochloride by High-performance Liquid Chromatography on Dynamically Modified Silica about?
A high-performance liquid chromatographic method was developed for the separation and determination of small amounts of impurities in dextropropoxyphene hydrochloride. The separation was achieved on a column of bare silica (LiChrosorb Si IOO), using as the eluent methanol-tetrahydrofuran-water-0.2 M potassium phosphate buffer (pH 7.5) (350:84:516:50) containing 2.5 mM cetyltrimethylammonium bromide. The selectivity of the system towards a mixture of dextropropoxyphene hydrochloride and two possible impurities was investigated using different brands of silica. Only minor variations were found relative to those of a chromatographic system based on chemically bonded ODS-silica as the column material. The method is well suited for pharmacopoeia1 purposes, especially as the utilization of reference substances is not necessary.
Who reads Determination of Impurities in Dextropropoxyphene Hydrochloride by High-performance Liquid Chromatography on Dynamically Modified Silica?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Sonja Kryger; Per Helboe
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 1991
- Language
- EN
- Field
- Chemistry (Physical Sciences)