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Can I read Studying Transcription Factor Function in the Genome at Molecular Resolution on EtoBox?
Studying Transcription Factor Function in the Genome at Molecular Resolution by Arnaud R. Krebs is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Studying Transcription Factor Function in the Genome at Molecular Resolution about?
About 7% of the human genome encodes cis-regulatory elements (CREs) that function as regulatory switches to modulate the expression of genes. These short genetic sequences control the complex transcriptional changes necessary for organismal development. A topical challenge in the field is to understand how transcription factors (TFs) read and translate this information into gene expression patterns. Here, I review how the development of single-molecule footprinting (SMF) that resolves the genome occupancy of TFs on individual DNA molecules resolution contributes to our ability to establish how the regulatory genetic information is interpreted at the mechanistic level. I further discuss how future developments in the nascent field of single-molecule genomics (SMG) could impact our understanding of gene regulation mechanisms.
Who reads Studying Transcription Factor Function in the Genome at Molecular Resolution?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Arnaud R. Krebs
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)