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GLP-1 Elicits An Intrinsic Gut-Liver Metabolic Signal To Ameliorate Diet-Induced VLDL Overproduction and Insulin Resistance by Anditri Weningtyas is a document available to read on EtoBox.
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The document investigates how complete disruption of subdiaphragmatic vagal signaling in mice results in a decrease in circulating VLDL-triglyceride levels compared to mice that underwent a sham procedure. Vagotomy prevented diet-induced obesity, hyperlipidemia, hepatic steatosis, and glucose intolerance in mice. Mechanistic studies showed that vagotomy increased plasma GLP-1 levels, which inhibited lipid synthesis and VLDL secretion in hepatocytes through reducing expression of genes involved in lipogenesi
- Author
- Anditri Weningtyas
- Language
- EN