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Criteria Used to Define Tumor Necrosis Factor-alpha Inhibitors Failure in Patients with Moderate-to-severe Psoriasis: a Systematic Literature Review by Isabel Belinchon Romero; Almudena Mateu Puchades; Miguel Ribera Pibernat; Diana. P. Ruiz Genao; Pablo de la Cueva Dobao; Jose Manuel Carrascosa is a Medicine article available to read on EtoBox.
What is Criteria Used to Define Tumor Necrosis Factor-alpha Inhibitors Failure in Patients with Moderate-to-severe Psoriasis: a Systematic Literature Review about?
## Abstract ## Background Determining tumor necrosis factor-alpha inhibitors (anti-TNF-α) failure is still a challenge in the management of moderate-to-severe psoriasis. Thus, our comprehensive systematic literature review aimed to gather information on the criteria used to define anti-TNF-α failure. We also aimed to discover the main reasons for anti-TNF-α failure and define subsequently administered treatments. ## Materials and methods We conducted a systematic review following review and reporting guidelines (Cochrane and PRISMA). International (Medline/PubMed and Cochrane Library) and Spanish databases (MEDES, IBECS), and gray literature were consulted to identify publications issued until April 2021 in English or Spanish. ## Results Our search yielded 58 publications. Of these, 37 (63.8%) described the criteria used to define anti-TNF-α primary or secondary failure. Criteria varied across studies, although around 60% considered Psoriasis Area and Severity Index (PASI)-50 criteria. Nineteen (32.8%) reported the reasons for treatment failure, including the lack or loss of efficacy and safety-related problems, mainly infections. Finally, 29 (50%) publications outlined the treatme
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- Author
- Isabel Belinchon Romero; Almudena Mateu Puchades; Miguel Ribera Pibernat; Diana. P. Ruiz Genao; Pablo de la Cueva Dobao; Jose Manuel Carrascosa
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)