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A fungal CFEM‐containing effector targets NPR1 regulator NIMIN2 to suppress plant immunity by Shengping Shang; Guangli Liu; Song Zhang; Xiaofei Liang; Rong Zhang; Guangyu Sun is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Summary __Colletotrichum fructicola__ causes a broad range of plant diseases worldwide and secretes many candidate proteinous effectors during infection, but it remains largely unknown regarding their effects in conquering plant immunity. Here, we characterized a novel effector CfEC12 that is required for the virulence of __C. fructicola__. CfEC12 contains a CFEM domain and is highly expressed during the early stage of host infection. Overexpression of CfEC12 suppressed BAX‐triggered cell death, callose deposition and ROS burst in __Nicotiana benthamiana__. CfEC12 interacted with apple MdNIMIN2, a NIM1‐interacting (NIMIN) protein that putatively modulates NPR1 activity in response to SA signal. Transient expression and transgenic analyses showed that MdNIMIN2 was required for apple resistance to __C. fructicola__ infection and rescued the defence reduction in __NbNIMIN2__‐silenced __N. benthamiana__, supporting a positive role in plant immunity. CfEC12 and MdNPR1 interacted with a common region of MdNIMIN2, indicating that CfEC12 suppresses the interaction between MdNIMIN2 and MdNPR1 by competitive target binding. In sum, we identified a fungal effector that targets the plant sa

Who reads A fungal CFEM‐containing effector targets NPR1 regulator NIMIN2 to suppress plant immunity?

Author

Shengping Shang; Guangli Liu; Song Zhang; Xiaofei Liang; Rong Zhang; Guangyu Sun

Publisher

John Wiley and Sons Inc.

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)