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Stem-17. Not All Gbm Stem Cells Are Equal: Implications For Research And Therapy by Luciano Galdieri; Arijita Jash; Olga Malkova; Diane Mao; Jian Campian; Cameron Brennan; Stephen Oh; Albert Kim; Milan Chheda is a Medicine article available to read on EtoBox.

What is Stem-17. Not All Gbm Stem Cells Are Equal: Implications For Research And Therapy about?

## Abstract Glioblastoma (GBM) kills almost all patients within 2 years. A subpopulation of cells, GBM stem cells (GSCs), contributes to treatment resistance and recurrence. A major therapeutic goal is to kill GSCs, but no targeted therapy yet exists. Since their discovery, GSCs have been isolated using single surface markers, such as CD15, CD44, CD133, and a-6 integrin. It remains unknown how these single surface marker-defined GSC populations compare to each other in terms of signal transduction and function and whether expression of different combinations of these markers is associated with distinct phenotypes. Using mass cytometry and fresh operating room specimens, we found that 15 distinct GSC subpopulations exist in vivo and they differ in their MEK/ERK, WNT, and AKT pathway activation status. In culture, some subpopulations were lost and previously undetectable ones materialized. GSCs highly expressing all four surface markers had the greatest self-renewal capacity and in vivo tumorigenicity as well as the strongest WNT pathway activation. This work highlights the signaling and phenotypic diversity in GSC subpopulations, together suggesting that not all GSCs are equivalent.

Who reads Stem-17. Not All Gbm Stem Cells Are Equal: Implications For Research And Therapy?

Author

Luciano Galdieri; Arijita Jash; Olga Malkova; Diane Mao; Jian Campian; Cameron Brennan; Stephen Oh; Albert Kim; Milan Chheda

Publisher

Oxford University Press (OUP)

Published

2020

Language

EN

Field

Medicine (Health Sciences)