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Morphology and Migration of Cultured Schwann Cells Transplanted Into the Fimbria and Hippocampus in Adult Rats by Gary A. Brook; Jean M. Lawrence; Geoffrey Raisman is a Neuroscience article available to read on EtoBox.

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## Abstract Schwann cells cultured from neonatal rat peripheral nerve were injected into the fimbria and hippocampus of syngeneic adult rats by a microtransplantation technique which causes minimal disturbance to the host brain structure at the site of implantation, and thus allows the grafted cells to come into immediate contact with intact host tissue. Numerous Schwann cells could be identified for up to 6 weeks (and with decreasing frequency for up to 3 months) by intense immunoreactivity for low affinity nerve growth factor receptor. The transplanted cells adopted a distinctive elongated form, with a central, ovoid nucleus flanked by processes which were up to 300 μm long, and which ranged from swollen segments with a diameter as large as 12 μm down to thread‐like fibres of 1 μm or less. This morphology is different from that of any of the host cells. The transplanted Schwann cells migrated freely into the host tissue along blood vessels and according to the position of the grafts, they either entered the hippocampal neuropil, or migrated (for distances of up to 2 mm) along the longitudinal axis of the fimbria, where they were interspersed in parallel with the interfascicular g

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Author

Gary A. Brook; Jean M. Lawrence; Geoffrey Raisman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)

Published

1993

Language

EN

Field

Neuroscience (Life Sciences)