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Hyperpolarized MRI – An Update and Future Perspectives by SH. Jørgensen; N. Bøgh; ESS. Hansen; M. Væggemose; H. Wiggers; C. Laustsen is a Medicine article available to read on EtoBox.

What is Hyperpolarized MRI – An Update and Future Perspectives about?

In recent years, hyperpolarized C magnetic resonance spectroscopic (MRS) imaging has emerged as a complementary metabolic imaging approach. Hyperpolarization via dissolution dynamic nuclear polarization is a technique that enhances the MR signal of 13 C-enriched molecules by a factor of > 10 4 , enabling detection downstream metabolites in a variety of intracellular metabolic pathways. The aim of the present review is to provide the reader with an update on hyperpolarized 13 C MRS imaging and to assess the future clinical potential of the technology. Several carbon-based probes have been used in hyperpolarized studies. However, the first and most widely used 13 C-probe in clinical studies is [1-13 C]pyruvate. In this probe, the enrichment of C is performed at the first carbon position as the only modification. Hyperpolarized [1-13 C]pyruvate MRS imaging can detect intracellular production of [1-13 C] lactate and 13 C-bicarbonate non-invasively and in real time without the use of ionizing radiation. Thus, by probing the balance between oxidative and glycolytic metabolism, hyperpolarized [1-13 C]pyruvate MRS imaging can image the Warburg effect in malignant tumors and detect the hall

Who reads Hyperpolarized MRI – An Update and Future Perspectives?

Author

SH. Jørgensen; N. Bøgh; ESS. Hansen; M. Væggemose; H. Wiggers; C. Laustsen

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)