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Early Predictors of Short‐Term Prognosis in Acute and Acute Severe Autoimmune Hepatitis by Maaike Biewenga; Akin Inderson; Maarten E. Tushuizen; A. Stijn L.P. Crobach; Bart van Hoek is a Medicine article available to read on EtoBox.

What is Early Predictors of Short‐Term Prognosis in Acute and Acute Severe Autoimmune Hepatitis about?

Presentation of autoimmune hepatitis (AIH) can differ from nonacute to acute autoimmune hepatitis (A‐AIH) with jaundice and acute severe autoimmune hepatitis (AS‐AIH) with jaundice and coagulopathy. The aim of the study was to evaluate the short‐term prognosis of different presentations of AIH and the influence of liver function improvement on short‐term prognosis. In this single‐center retrospective cohort study, AIH patients with repeatedly tested liver function at diagnosis and during at least 1 year of follow‐up were included. A‐AIH was defined as bilirubin >45 μmol and international normalized ratio (INR) 45 μmol/L and INR ≥1.5. Of the 81 included patients, 17 (21%) presented with A‐AIH, and 14 (17%) presented with AS‐AIH. After the start of immunosuppressive therapy, bilirubin, albumin, and INR normalized in 70%, 77%, and 69%, respectively, in a median of 2.6 months, 3 months, and 4 weeks, respectively, in patients with A‐AIH and AS‐AIH. Liver transplantation (LT)–free survival rate was 100% in nonacute AIH, 94% in A‐AIH, and 57% in AS‐AIH at 12 months after diagnosis. An increase of INR or bilirubin at 2 weeks was the best predictive factor for the need of LT within 12 mont

Who reads Early Predictors of Short‐Term Prognosis in Acute and Acute Severe Autoimmune Hepatitis?

Author

Maaike Biewenga; Akin Inderson; Maarten E. Tushuizen; A. Stijn L.P. Crobach; Bart van Hoek

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)