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The document reviews various methods to enhance the solubility of Efavirenz (EFV), an antiretroviral drug used for HIV/AIDS treatment, due to its poor aqueous solubility and variable bioavailability. Techniques such as Nano Micelles, Wet Milling, Co-crystals, and Nanocrystals have shown significant improvements in dissolution rates, with studies reporting enhancements in solubility from 1.00 mg/mL to 2.30 mg/mL and dissolution efficiencies exceeding 98%. The findings aim to guide the development of more eff

Author

Alfina Rahmawati

Language

EN