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Mathematical Model of Fibroblast Dynamics by Riccardo Spinoza Silva is a document available to read on EtoBox.
This paper develops a mathematical model to simulate the large membrane deformations observed in isolated fibroblasts. The model extends a previous model used to describe the dynamics of round cells. It describes cell membrane deformations as resulting from a balance of intracellular protrusive and cortical actin-generated retractive forces, modulated by membrane curvature stress. Simulations reproduce the oscillatory protrusive behavior of fibroblasts, with large pseudopods periodically extending in opposi
- Author
- Riccardo Spinoza Silva
- Language
- EN