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Role of high-molecular weight tropomyosins in TGF-β-mediated control of cell motility by Qiao Zheng; Alfiya Safina; Andrei V. Bakin is a Medicine article available to read on EtoBox.

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## Abstract Transforming growth factor beta1 (TGF‐β1) suppresses tumor development at early stages of cancer, but enhances tumor invasion and formation of metastasis. TGF‐β1‐mediated tumor invasion is associated with epithelial to mesenchymal transition (EMT) and matrix proteolysis. The mechanisms of these TGF‐β1 responses in normal and tumor cells are not well understood. Recently, we have reported that TGF‐β1 increases expression of high‐molecular weight tropomyosins (HMW‐tropomyosins) and formation of actin stress fibers in normal epithelial cells. The present study investigated the role of tropomyosin in TGF‐β1‐mediated cell motility and invasion. We found that TGF‐β1 restricts motility of normal epithelial cells although it promotes EMT and formation of actin stress fibers and focal adhesions. Cell motility was enhanced by siRNA‐mediated suppression of HMW‐tropomyosins. TGF‐β1 stimulated migration and matrix proteolysis in breast cancer MDA‐MB‐231 cells that express low levels of HMW‐tropomyosins. Tet‐Off‐regulated expression of HMW‐tropomyosin inhibited cell migration and matrix proteolysis without affecting expression of matrix metalloproteinases. Tropomyosin increased cell

Who reads Role of high-molecular weight tropomyosins in TGF-β-mediated control of cell motility?

Author

Qiao Zheng; Alfiya Safina; Andrei V. Bakin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2007

Language

EN

Field

Medicine (Health Sciences)