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Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline: Synthesis, DNA-binding and photocleavage studies by Yun-Jun Liu; Hui Chao; Yi-Xian Yuan; Hui-Juan Yu; Liang-Nian Ji is a Chemistry article available to read on EtoBox.
What is Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline: Synthesis, DNA-binding and photocleavage studies about?
Two novel Ru(II) complexes [Ru(bpy) 2 (MCMIP)] 2+ (1) and [Ru(phen) 2 (MCMIP)] 2+ (2) (bpy = 2,2 0 -bipyridine; phen = 1,10-phenanthroline; MCMIP = 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline) have been synthesized and characterized by elemental analysis, mass spectra and 1 H NMR. The DNA-binding properties of the complexes were investigated by absorption, emission, melting temperature and viscosity measurements. Experimental results indicate that the two complexes can intercalate into DNA base pairs. Upon irradiation at 365 nm, two Ru(II) complexes were found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II, and the mechanisms for DNA cleavage by the complexes were also investigated.
Who reads Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline: Synthesis, DNA-binding and photocleavage studies?
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- Author
- Yun-Jun Liu; Hui Chao; Yi-Xian Yuan; Hui-Juan Yu; Liang-Nian Ji
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0020-1693)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)