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The study identifies Ndl1, a homologue of NudEL in budding yeast, which plays a crucial role in targeting dynein to microtubule plus ends through its interaction with LIS1. The absence of Ndl1 leads to decreased dynein localization at microtubule ends and affects mitotic spindle positioning, indicating its importance in dynein function. The findings suggest a model where Ndl1 transiently binds to microtubule plus ends to facilitate the recruitment of LIS1, which in turn recruits dynein.

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ivor1658177216

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EN