Can I read Discriminative stimulus effects of the novel imidazoline I~2~ receptor ligand CR4056 in rats on EtoBox?

Discriminative stimulus effects of the novel imidazoline I~2~ receptor ligand CR4056 in rats by Qiu, Yanyan; He, Xiao-Hua; Zhang, Yanan; Li, Jun-Xu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Discriminative stimulus effects of the novel imidazoline I~2~ receptor ligand CR4056 in rats about?

This study examined whether a novel imidazoline I2 receptor ligand CR4056 could serve as a discriminative stimulus and whether it shares similar discriminative stimulus effects with other reported I2 receptor ligands. Eight male Sprague-Dawley rats were trained to discriminate 10.0 mg/kg CR4056 (i.p.) from vehicle in a two-lever food-reinforced drug discrimination procedure. Once rats acquired the discrimination, substitution and combination studies were conducted to elucidate the underlying receptor mechanisms. All rats acquired CR4056 discrimination after an average of 26 training sessions. Several I2 receptor ligands (phenyzoline, tracizoline, RS45041, and idazoxan, 3.2-75 mg/kg, i.p.) all occasioned > 80% CR4056-associated lever responding. Other drugs that occasioned partial or no CR4056-associated lever responding included methamphetamine, ketamine, the endogenous imidazoline ligand agmatine, the monoamine oxidase (MAO) inhibitor harmane, the α2-adrenoceptor agonist clonidine, the μ-opioid receptor agonists morphine and methadone, and the selective I2 receptor ligands BU224 and 2-BFI. The α1 adrenoceptor antagonist WB4101, α2 adrenoceptor antagonist yohimbine and μ-opioid rec

Who reads Discriminative stimulus effects of the novel imidazoline I~2~ receptor ligand CR4056 in rats?

Author

Qiu, Yanyan; He, Xiao-Hua; Zhang, Yanan; Li, Jun-Xu

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2014

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)