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Transforming properties of TC‐1 in human breast cancer: Interaction with FGFR2 and β‐catenin signaling pathways by Zeng‐Quan Yang; Allison B. Moffa; Ramsi Haddad; Katie L. Streicher; Stephen P. Ethier is a Medicine article available to read on EtoBox.
What is Transforming properties of TC‐1 in human breast cancer: Interaction with FGFR2 and β‐catenin signaling pathways about?
## Abstract Breast cancer development is associated with gene amplification and over expression that is believed to have a causative role in oncogenesis. Previous studies have demonstrated that over expression of __TC‐1__(__C8orf4__) mRNA occurs in ∼50% of breast cancer cell lines and primary tumor specimens. Here, we show that TC‐1 has transforming properties in human mammary epithelial (HME) cells and its expression is mechanistically linked to FGFR signaling cascades. __In vitro__ experiments demonstrate that TC‐1 over expression mediates both anchorage‐independent and growth factor‐independent proliferation of HME cells. __TC‐1__ was down regulated by the FGFR inhibitor PD173074 in the breast cancer cell line SUM‐52 that also has an FGFR2 gene amplification and over expression. Furthermore, forced expression of FGFR2 in HME cells increased the level of expression of endogenous __TC‐1__ mRNA. TC‐1 has been implicated as a modulator of Wnt/β‐catenin signaling in 293 cells and in gastric cancer cells. However, while we did find increased expression of a subset of β‐catenin target genes in TC‐1 over expressing cells, we did not find an association of TC‐1 with global expression of
Who reads Transforming properties of TC‐1 in human breast cancer: Interaction with FGFR2 and β‐catenin signaling pathways?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Zeng‐Quan Yang; Allison B. Moffa; Ramsi Haddad; Katie L. Streicher; Stephen P. Ethier
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)