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Inhibitory Potential of Apium graveolens L. Extract on Inflammation in Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice by Anisha Lyngdoh; Taranga Jyoti Baruah; Rajeshwar Nath Sharan; Lakhon Kma is a Medicine article available to read on EtoBox.

What is Inhibitory Potential of Apium graveolens L. Extract on Inflammation in Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice about?

## Background Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with a recurrence rate of 80–90% and a high mortality rate. It is an inflammation-related cancer where cytokines production plays a major role, resulting in a non-resolving inflammation in the tumor microenvironment, which promotes the disease. Therefore, targeting inflammation is a logical way to combat HCC. Natural products can be helpful in the co-treatment and prevention of HCC. ## Hypothesis This study aimed to evaluate the hepatoprotective properties of a methanolic extract of Apium graveolens L. (MAG) in diethylnitrosamine (DEN)-induced toxicity in BALB/c mice. ## Materials and Methods We checked the antioxidant, anti-inflammatory, and anti-cancer properties of MAG. DEN is known to induce oxidative stress by increasing reactive oxygen species (ROS) production. This can result in liver damage, increased SGOT, SGPT, and ALP activity in serum, increased expression of HCC biomarkers like AFP and GPC-3, and increased levels of the inflammatory biomarkers NF-κB, IL-6, IL-4, IL-1β, and TNF-α. The above factors can cause the activation of the inflammatory signaling pathways, triggering the developm

Who reads Inhibitory Potential of Apium graveolens L. Extract on Inflammation in Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice?

Author

Anisha Lyngdoh; Taranga Jyoti Baruah; Rajeshwar Nath Sharan; Lakhon Kma

Publisher

SAGE Publications

Published

2023

Language

EN

Field

Medicine (Life Sciences)