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Can I read Soluble α-Klotho and Heparin Modulate the Pathologic Cardiac Actions of Fibroblast Growth Factor 23 in Chronic Kidney Disease on EtoBox?
Soluble α-Klotho and Heparin Modulate the Pathologic Cardiac Actions of Fibroblast Growth Factor 23 in Chronic Kidney Disease by Christopher Yanucil; Dominik Kentrup; Isaac Campos; Brian Czaya; Kylie Heitman; David Westbrook; Gunars Osis; Alexander Grabner; Adam R. Wende; Julian Vallejo; Michael J. Wacker; Jose Alberto Navarro-Garcia; Gema Ruiz-Hurtado; Fuming Zhang; Yuefan Song; Robert J. Linhardt; Kenneth White; Michael S. Kapiloff; Christian Faul is a Medicine article available to read on EtoBox.
What is Soluble α-Klotho and Heparin Modulate the Pathologic Cardiac Actions of Fibroblast Growth Factor 23 in Chronic Kidney Disease about?
Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in patients with chronic kidney disease and associated with cardiovascular mortality. Experimental studies showed that elevated FGF23 levels induce cardiac hypertrophy by targeting cardiac myocytes via FGF receptor isoform 4 (FGFR4). A recent structural analysis revealed that the complex of FGF23 and FGFR1, the physiologic FGF23 receptor in the kidney, includes soluble α-klotho (klotho) and heparin, which both act as co-factors for FGF23/FGFR1 signaling. Here, we investigated whether soluble klotho, a circulating protein with cardio-protective properties, and heparin, a factor that is routinely infused into patients with kidney failure during the hemodialysis procedure, regulate FGF23/FGFR4 signaling and effects in cardiac myocytes. We developed a plate-based binding assay to quantify affinities of specific FGF23/FGFR interactions and found that soluble klotho and heparin mediate FGF23 binding to distinct FGFR isoforms. Heparin specifically mediated FGF23 binding to FGFR4 and increased FGF23 stimulatory effects on hypertrophic growth and contractility in isolated cardiac myocytes. When repetitively
Who reads Soluble α-Klotho and Heparin Modulate the Pathologic Cardiac Actions of Fibroblast Growth Factor 23 in Chronic Kidney Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Christopher Yanucil; Dominik Kentrup; Isaac Campos; Brian Czaya; Kylie Heitman; David Westbrook; Gunars Osis; Alexander Grabner; Adam R. Wende; Julian Vallejo; Michael J. Wacker; Jose Alberto Navarro-Garcia; Gema Ruiz-Hurtado; Fuming Zhang; Yuefan Song; Robert J. Linhardt; Kenneth White; Michael S. Kapiloff; Christian Faul
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)