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The Sensitivity and Specificity of Split-Hand Index Using Muscle Sonography by Reuven Avidan; Yaara Fainmesser; Vivian E. Drory; Vera Bril; Alon Abraham is a Medicine article available to read on EtoBox.

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## ABSTRACT: ## Background: The split-hand index (SHI) (first dorsal interosseous (FDI) × abductor pollicis brevis (APB)/abductor digiti minimi muscle (ADM)) has been suggested as a useful measure for amyotrophic lateral sclerosis (ALS) diagnosis, using electrophysiological and sonographic indices. In the present study, we aimed to explore the specificity of SHI derived by muscle ultrasound (MUS) for the diagnosis of ALS and spinal muscular atrophy (SMA). ## Methods: Healthy controls (n = 65) were prospectively recruited at the Prosserman Family Neuromuscular clinic at Toronto General Hospital, from October to December 2018. In addition, 181 patients with ALS (n = 91), SMA (n = 33), polyneuropathy (n = 35), and myopathy (n = 22) were prospectively recruited at the neuromuscular clinic at Tel Aviv Sourasky Medical Center, from December 2018 to December 2020. All subjects underwent quantitative sonographic evaluation of muscle thickness, including the right APB, FDI, and ADM muscles. Area under curve (AUC), sensitivity, and specificity were determined for differentiating between groups. ## Results: Although SHI showed good to excellent accuracy for differentiating each patient subgro

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Author

Reuven Avidan; Yaara Fainmesser; Vivian E. Drory; Vera Bril; Alon Abraham

Publisher

Cambridge University Press (CUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)