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Highly Enantioselective One-pot Sequential Synthesis of Valerolactones and Pyrazolones Bearing All-carbon Quaternary Stereocentres by Yan-Li Xu; Zhou-Zhou Qin; Yu-Xia Wang; Peng-Fei Zhao; Hong-Feng Li; Zhi-Hong Du; Chao-Shan Da is a Chemistry article available to read on EtoBox.
What is Highly Enantioselective One-pot Sequential Synthesis of Valerolactones and Pyrazolones Bearing All-carbon Quaternary Stereocentres about?
Highly enantiopure and bioactive δ-valerolactones and pyrazolones, bearing α-all-carbon quaternary stereocentres, were successfully and sequentially prepared via a one-pot procedure starting from readily available, inexpensive materials, catalysed by a new chiral squaramide under mild reaction conditions. An organocatalytic Michael reaction afforded the valerolactones, while a one-pot Michael-hydrazinolysis-imidization cascade yielded the pyrazolones. This procedure is economically efficient and environmentally benign.
Who reads Highly Enantioselective One-pot Sequential Synthesis of Valerolactones and Pyrazolones Bearing All-carbon Quaternary Stereocentres?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Yan-Li Xu; Zhou-Zhou Qin; Yu-Xia Wang; Peng-Fei Zhao; Hong-Feng Li; Zhi-Hong Du; Chao-Shan Da
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)