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Can I read Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis on EtoBox?
Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis by Mahima Sharma; Palika Abayakoon; Ruwan Epa; Yi Jin; James P. Lingford; Tomohiro Shimada; Masahiro Nakano; Janice W.-Y. Mui; Akira Ishihama; Ethan D. Goddard-Borger; Gideon J. Davies; Spencer J. Williams is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis about?
The sulfosugar sulfoquinovose (SQ) is produced by essentially all photosynthetic organisms on Earth and is metabolized by bacteria through the process of sulfoglycolysis. The sulfoglycolytic Embden–Meyerhof–Parnas pathway metabolizes SQ to produce dihydroxyacetone phosphate and sulfolactaldehyde and is analogous to the classical Embden–Meyerhof–Parnas glycolysis pathway for the metabolism of glucose-6-phosphate, though the former only provides one C3 fragment to central metabolism, with excretion of the other C3 fragment as dihydroxypropanesulfonate. Here, we report a comprehensive structural and biochemical analysis of the three core steps of sulfoglycolysis catalyzed by SQ isomerase, sulfofructose (SF) kinase, and sulfofructose-1-phosphate (SFP) aldolase. Our data show that despite the superficial similarity of this pathway to glycolysis, the sulfoglycolytic enzymes are specific for SQ metabolites and are not catalytically active on related metabolites from glycolytic pathways. This observation is rationalized by three-dimensional structures of each enzyme, which reveal the presence of conserved sulfonate binding pockets. We show that SQ isomerase acts preferentially on the β-ano
Who reads Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mahima Sharma; Palika Abayakoon; Ruwan Epa; Yi Jin; James P. Lingford; Tomohiro Shimada; Masahiro Nakano; Janice W.-Y. Mui; Akira Ishihama; Ethan D. Goddard-Borger; Gideon J. Davies; Spencer J. Williams
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)