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A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson’s disease by Jayoung Kim; Yongsheng Gao; Zongmin Zhao; Danika Rodrigues; Eden E. L. Tanner; Kelly Ibsen; Pradip K. Sasmal; Rajasekhar Jaladi; Shanavas Alikunju; Samir Mitragotri is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson’s disease about?

## Significance Parkinson’s disease (PD) is a progressive disorder of the central nervous system that affects motor control. While subcutaneous injection of apomorphine (Apokyn) is clinically used to alleviate intermittent episodes of dyskinesia, the treatment requires multiple injections of the drug per day, significantly deterring patient compliance. We introduce a deep eutectic-based ternary solvent system that self-emulsifies in situ following subcutaneous injection and entraps apomorphine, allowing a 48-h duration of detectable drug concentration in the plasma of pigs, which is a remarkable improvement over the clinical comparator. The results from the animal studies support the self-emulsifying system as a potent, long-lasting therapeutic for PD patients and potentially for other therapeutics that have a similar delivery challenge.

Who reads A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson’s disease?

Author

Jayoung Kim; Yongsheng Gao; Zongmin Zhao; Danika Rodrigues; Eden E. L. Tanner; Kelly Ibsen; Pradip K. Sasmal; Rajasekhar Jaladi; Shanavas Alikunju; Samir Mitragotri

Publisher

Proceedings of the National Academy of Sciences

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)