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Association between handgrip strength, nonalcoholic fatty liver disease, advanced hepatic fibrosis and its modifiers: Evidence from the NHANES database of the USA by Xiaohong Zhao; Xuexue Shi; Haifeng Gu; Wenjing Zhou; Qin Zhang is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Aim Nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF) have been associated with sarcopenia. However, modifiers of this association have been less studied. ## Methods This study used data from the NHANES database 2011–2014 of the USA. Adults aged 18 years or older, had complete information of handgrip strength test and NAFLD and AHF status were eligible for inclusion. NAFLD was defined using the Fatty Liver Index (FLI). AHF was defined using the NAFLD fibrosis score (NFS). Univariate and multivariate logistic regression were performed to determine the associations between the study variables and prevalent NAFLD and AHF. ## Results A total of 19 931 participants were selected from the 2011–2014 NHANES database. The multivariate analysis showed that stronger grip strength was significantly and independently associated with decreased odds for NAFLD (tertile 2: adjusted odd ratio [aOR]: 0.41, 95% confidence interval [CI]: 0.29–0.59; tertile 3: aOR: 0.11, 95% CI: 0.05–0.24) and AHF (tertile 2: aOR: 0.66, 95% CI: 0.46–0.94; tertile 3: aOR: 0.28, 95% CI: 0.12–0.63). In stratified analyses, strongest grip strength was significantly as

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Author

Xiaohong Zhao; Xuexue Shi; Haifeng Gu; Wenjing Zhou; Qin Zhang

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)