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Hansch Analysis of Substituted Benzoic Acid Benzylidene/furan-2-yl-methylene Hydrazides as Antimicrobial Agents by Pradeep Kumar; Balasubramanian Narasimhan; Deepika Sharma; Vikramjeet Judge; Rakesh Narang is a Chemistry article available to read on EtoBox.

What is Hansch Analysis of Substituted Benzoic Acid Benzylidene/furan-2-yl-methylene Hydrazides as Antimicrobial Agents about?

A series of substituted hydrazide derivatives have been synthesized and screened for their in vitro antimicrobial activities against five representative microorganisms. The results of antimicrobial study indicated that the presence of electron withdrawing groups on the benzoic acid moiety improved antimicrobial activity. Further, the presence of heterocyclic ring furan does not improve the antimicrobial activity of substituted hydrazides. To understand the relationship between physicochemical parameters and antimicrobial activity of substituted hydrazide derivatives, QSAR investigation was performed by the development of one-target and multi-target models. The multi-target model was found to be effective in describing the antimicrobial activity of substituted hydrazides in comparison to the one-target models. Further, it indicated the importance of the topological parameter, valence third order molecular connectivity index ( 3 c v ) and the electronic parameter, energy of highest occupied molecular orbital (HOMO) in describing the antimicrobial activity of substituted hydrazides.

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Author

Pradeep Kumar; Balasubramanian Narasimhan; Deepika Sharma; Vikramjeet Judge; Rakesh Narang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)