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Anti‐diabetic effect of standardized extract of \ \ Potentilla discolor\ \ Bunge and identification of its active components by Jie Yang; Hong Chen; Li Zhang; Qiang Wang; Mao‐Xiang Lai is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract __Potentilla discolor__ Bunge, a Chinese folk medicine, has been used for the treatment of diabetes for many years. Unfortunately, little information is available on its bioactive components and mechanism of action. We report the anti‐diabetic effect of __P. discolor__ on normal and alloxan‐induced diabetic mice, as well as the possible constituents and mechanism responsible for this activity. We found that the standardized extract of __P. discolor__ (EPD) had little effect on the glucose levels of normal mice, while a dose‐dependent hypoglycemic effect was observed in diabetic mice. Glucose tolerance test data indicated that there was a significantly higher rate of glucose disposal after EPD treatment. Phytochemical characterization indicated that the major components of EPD were triterpenes and flavonoids that could inhibit the activity of glycogen phosphorylase (GP) in vitro. Tormentic acid, asiatic acid, and potengriffioside A exhibited inhibitory effects on GP (IC~50~=90.6, 65.4, and 85.9 μM, respectively). The inhibition on GP may be one molecular mechanism through which EPD ameliorates hyperglycemia. These results suggest __P. discolor__ extract may offer an alte

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Author

Jie Yang; Hong Chen; Li Zhang; Qiang Wang; Mao‐Xiang Lai

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0272-4391)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)