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Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway by Bo-Han Wang; Ling-Ling Tang; Xian-Hong Sun; Qian Zhang; Chun-Yang Liu; Xiao-Na Zhang; Ke-Yao Yu; Ying Yang; Jun Hu; Xiao-Lu Shi; Yue Wang; Li Liu is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway about?

Ethnopharmacological relevance: Excessive secretion of airway mucus may be an important pathological factor of air pollution-induced acute asthma attacks. Treatment of airway mucus hypersecretion improves asthma aggravated by air pollutants. Qufeng Xuanbi Formula (QFXBF) has been used to treat asthma for more than 30 years. However, whether QFXBF inhibits asthmatic mucus secretion exacerbated by air pollutants has not yet been established. Aim of the study: This study aimed to evaluate the effect of QFXBF on airway mucus secretion and the mechanism of action in an air pollutant benzo[a]pyrene (BaP)-induced mouse model of aggravated asthma. Materials and methods: Ovalbumin (OVA) and BaP co-exposure were used to establish the aggravated asthma model. The average enhanced pause (Penh), serum OVA-specific IgE, and changes in lung histopathology were determined. 16HBE cells exposed to BaP, treatment with QFXBF, arylhydrocarbon receptor (AhR) signal antagonist SR1, reactive oxygen species (ROS) antagonist NAC, or extracellular signal-regulated kinase (ERK1/2) signal antagonist U0126 were established to investigate the effect of QFXBF on BaP-induced mucus secretion and its target. The mRN

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Author

Bo-Han Wang; Ling-Ling Tang; Xian-Hong Sun; Qian Zhang; Chun-Yang Liu; Xiao-Na Zhang; Ke-Yao Yu; Ying Yang; Jun Hu; Xiao-Lu Shi; Yue Wang; Li Liu

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)