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Preliminary Results in 185 Patients Treated with Accelerated Partial Breast Irradiation for Early-stage Breast Cancer by K.M. Tokita; L. Chittenden; M.K. Nelson; A. Hayes; C. Sheffield; R. Khanijou; L. Curcio; J. Ravera; R.B. Wilder is a Medicine article available to read on EtoBox.
What is Preliminary Results in 185 Patients Treated with Accelerated Partial Breast Irradiation for Early-stage Breast Cancer about?
Results: Median follow-up time was 34 months. There was considerable variation in maximum skin dose among patients with a common skin distance (mean standard deviation of 40 cGy). A significant correlation was found between incidence of acute moist desquamation and a maximum skin dose .410 cGy (120% prescription dose, p = 0.014) or a skin distance \8 mm (p = 0.025). Correlations were found between a maximum skin dose .400 cGy and incidence of chronic induration (p = 0.042) and chronic erythema (borderline significant, p = 0.051). Incidence of telangiectasia was found to increase continuously with closer skin distance (p = 0.0006) and maximum skin dose (p = 0.0003) with no threshold found #10 mm or .210 cGy. Conclusions: Maximum planned skin dose was found to correlate with incidence of acute moist desquamation, telangiectasia, chronic erythema, and chronic induration resulting from MammoSite APBI. This correlation supports the empirically validated use of minimum balloon-to-skin distance as a predictor of toxicity from MammoSite treatment. We expect that as more sophisticated brachytherapy dose calculation methods evolve, calculated maximum skin dose will improve correspondingly as
Who reads Preliminary Results in 185 Patients Treated with Accelerated Partial Breast Irradiation for Early-stage Breast Cancer?
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- Author
- K.M. Tokita; L. Chittenden; M.K. Nelson; A. Hayes; C. Sheffield; R. Khanijou; L. Curcio; J. Ravera; R.B. Wilder
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)