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GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleus by Wen-Bin Len; Julie Y.H. Chan is a Neuroscience article available to read on EtoBox.
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## Abstract We investigated the role of GABAergic neurotransmission at the nucleus tractus solitarii (NTS) in the suppression of cardiac baroreceptor reflex (BRR) response induced by parabrachial nucleus (PBN) complex in adult Sprague‐Dawley rats maintained under pentobarbital anesthesia. Based on in vivo microdialysis coupled with high‐performance liquid chromatography‐fluorescence detection for γ‐aminobutyric acid (GABA), we found that electrical stimulation of the ventrolateral regions and Koelliker‐Fuse (KF) subnucleus of PBN complex resulted in a site‐specific increase in GABA concentration in the dialysate collected from the NTS. The temporal increase in extracellular GABA concentration in the NTS coincided with the time course of PBN‐induced cardiac BRR inhibition. In addition, the PBN‐induced cardiac BRR suppression was reversed by microinjection bilaterally into the NTS of a GABA~A~ receptor antagonist, bicuculline methiodide (5 pmol), or a GABA~B~ receptor antagonist, 2‐OH saclofen (500 pmol). Blockade of neuronal activity in the ventrolateral regions and KF subnucleus of PBN complex with lidocaine (5%) elicited an enhancement of the same reflex response. The time course
Who reads GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleus?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Wen-Bin Len; Julie Y.H. Chan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)