Opening book details…
Can I read Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps on EtoBox?
Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps by Ting Wang; Yingli Zhou; Zilong Zhou; Pinggen Zhang; Ronghui Yan; Linchong Sun; Wenhao Ma; Tong Zhang; Shengqi Shen; Haiying Liu; Hui Lu; Ling Ye; Junru Feng; Zhaolin Chen; Xiuying Zhong; Gao Wu; Yongping Cai; Weidong Jia; Ping Gao; Huafeng Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps about?
Hepatocytes function largely through the secretion of proteins that regulate cell proliferation, metabolism, and intercellular communications. During the progression of hepatocellular carcinoma (HCC), the hepatocyte secretome changes dynamically as both a consequence and a causative factor in tumorigenesis, although the full scope of secreted protein function in this process remains unclear. Here, we show that the secreted pseudo serine protease PRSS35 functions as a tumor suppressor in HCC. Mechanistically, we demonstrate that active PRSS35 is processed via cleavage by proprotein convertases. Active PRSS35 then suppresses protein levels of CXCL2 through targeted cleavage of tandem lysine (KK) recognition motif. Consequently, CXCL2 degradation attenuates neutrophil recruitment to tumors and formation of neutrophil extracellular traps, ultimately suppressing HCC progression. These findings expand our understanding of the hepatocyte secretome’s role in cancer development while providing a basis for the clinical translation of PRRS35 as a therapeutic target or diagnostic biomarker.
Who reads Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ting Wang; Yingli Zhou; Zilong Zhou; Pinggen Zhang; Ronghui Yan; Linchong Sun; Wenhao Ma; Tong Zhang; Shengqi Shen; Haiying Liu; Hui Lu; Ling Ye; Junru Feng; Zhaolin Chen; Xiuying Zhong; Gao Wu; Yongping Cai; Weidong Jia; Ping Gao; Huafeng Zhang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)