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Localization of proteins that are coordinately expressed with Cln2 during the cell cycle by Bryan A. Sundin; Chun‐Hwei Chiu; Michael Riffle; Trisha N. Davis; Eric G. D. Muller is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Localization of proteins that are coordinately expressed with Cln2 during the cell cycle about?
## Abstract The localization of proteins can give important clues about their function and help sort data from large‐scale proteomic screens. Forty‐five proteins were tagged with the GFP variant YFP. These proteins were chosen because they are encoded by genes that display strong cell cycle‐dependent expression that peaks in G~1~. Most of these proteins localize to either the nucleus or to sites of cell growth. We are able to assign new cellular component GO terms to ASF2, TOS4, RTT109, YBR070C, YKR090W, YOL007C, YOL019W and YPR174C. We also have localization data for 21 other proteins. Noteworthy localizations were found for Rfa1p, a member of the DNA replication A complex, and Pri2p and Pol12p, subunits of the α‐DNA polymerase : primase complex. In addition to its nuclear localization, Rfa1p assembled into cytoplasmic foci adjacent to the nucleus in cells during the G~1~–S phase transition of the cell cycle. Pri2 and Pol12 took on a beaded appearance at the G~1~–S transition and later in the cell cycle were enriched in the nuclear envelope. A new spindle pole body/nuclear envelope component encoded by YPR174 was identified. The cell cycle‐dependent abundance of Tos4p mirrored Yox
Who reads Localization of proteins that are coordinately expressed with Cln2 during the cell cycle?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bryan A. Sundin; Chun‐Hwei Chiu; Michael Riffle; Trisha N. Davis; Eric G. D. Muller
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)