Can I read Bioorganic Chemistry: Sciencedirect on EtoBox?

Bioorganic Chemistry: Sciencedirect by Nguyen Quang Khai is a document available to read on EtoBox.

What is Bioorganic Chemistry: Sciencedirect about?

This document describes the design, synthesis, and evaluation of novel N-hydroxybenzamides and N-hydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents. Several compounds showed potent HDAC inhibition and cytotoxicity against cancer cell lines, with some compounds being more potent than SAHA. Docking experiments provided insights into features contributing to inhibitory activity, and predicted binding energies correlated well with experimental results.

Author

Nguyen Quang Khai

Language

EN