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Dose-Volume Response in Acute Gastrointestinal Injury of Prostate Cancer Patients Treated With Helical Tomotherapy by J.C. Cheng; T.E. Schultheiss; K. Nguyen; J.Y.C. Wong is a Medicine article available to read on EtoBox.

What is Dose-Volume Response in Acute Gastrointestinal Injury of Prostate Cancer Patients Treated With Helical Tomotherapy about?

Materials/Methods: From 1988-2005, 855 pts were treated with definitive RT for non-metastatic prostate cancer. Seventy-one pts (median age 72 yrs) were retrospectively identified to have a history of TURP prior to RT. The median PSA was 9 ng/mL (range, 0.2-874) and the staging distribution was: T Stage (56% T1, 33% T2, 11% T3), N stage (84% N0, 3% N1, 7% NX) and Gleason Score (63% GS 4-6, 28% GS 7, 9% GS 8-10). All pts were treated with external beam RT to a median dose of 70 Gy (range, 45-76.4), of which 24% had IMRT, 7% had whole pelvic RT, and 1 patient had a brachytherapy boost of 108 Gy. Hormone therapy was given in 28% of pts for a median of 4 mo. TURP was performed once in 78%, twice in 20%, and three times in 1% of pts. The median amount of prostate tissue removed was 16.5 g (range, 2.5-96) and the median time from TURP to RT was 9.8 mo (range, 0.7-301). The pre-treatment median IPSS score was 9 (range, 1-32) and the median urologic quality of life score was 2 (range, 1-5). Acute toxicity was scored by RTOG criteria and late toxicity was scored by CTCAE v3.0 criteria. Results: The median follow-up of all 71 pts was 32 mo (0.5-169). The 3Y freedom from biochemical failure (n

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Author

J.C. Cheng; T.E. Schultheiss; K. Nguyen; J.Y.C. Wong

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)