Can I read Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease on EtoBox?

Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease by Maria J. Reimann; Merete Fredholm; Signe E. Cremer; Liselotte B. Christiansen; Kathryn M. Meurs; Jacob E. Møller; Jens Häggström; Jens Lykkesfeldt; Lisbeth H. Olsen is a Medicine article available to read on EtoBox.

What is Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease about?

## Abstract ## Background The neurotransmitter serotonin (5‐HT) affects valvular degeneration and dogs with myxomatous mitral valve disease (MMVD) exhibit alterations in 5‐HT signaling. In Maltese dogs, 3 single nucleotide polymorphisms (SNPs) in the 5‐HT transporter (SERT) gene are suggested to associate with MMVD. ## Hypothesis/Objectives Determine the association of SERT polymorphisms on MMVD severity and serum 5‐HT concentration in Cavalier King Charles Spaniels (CKCS). Additionally, investigate the association between selected clinical and hematologic variables and serum 5‐HT and assess the correlation between HPLC and ELISA measurements of serum 5‐HT. ## Animals Seventy‐one CKCS (42 females and 29 males; 7.8 [4.7;9.9] years (median [Q1;Q3])) in different MMVD stages. ## Methods This prospective study used TaqMan genotyping assays to assess SERT gene polymorphisms. Neurotransmitter concentrations were assessed by HPLC and ELISA. ## Results TaqMan analyses identified none of the selected SERT polymorphisms in any of the CKCS examined. Serum 5‐HT was associated with platelet count (__P__ < .001) but not MMVD severity, age or medical therapy and did not correlate with serum conce

Who reads Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease?

Author

Maria J. Reimann; Merete Fredholm; Signe E. Cremer; Liselotte B. Christiansen; Kathryn M. Meurs; Jacob E. Møller; Jens Häggström; Jens Lykkesfeldt; Lisbeth H. Olsen

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)