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This document summarizes linear molecular motors and their stepping mechanisms. It discusses one-state ratchet models that assume motors make forward and backward steps between equivalent states. However, experimental evidence shows motor dwell time distributions are bi-exponential, indicating they have at least two states. More detailed two-state ratchet models are needed to decouple ATP hydrolysis from physical movement through intermediate states. This allows the chemical and mechanical cycles to operate

Author

Jared Lo

Language

EN