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Caenorhabditis Elegans: a Model Organism in the Toxicity Assessment of Environmental Pollutants by Nguyen Phuoc Long; Jong Seong Kang; Hyung Min Kim is a Environmental Science article available to read on EtoBox.
What is Caenorhabditis Elegans: a Model Organism in the Toxicity Assessment of Environmental Pollutants about?
The unfavorable effects of environmental pollutants are becoming increasingly evident. In recent years, Caenorhabditis elegans (C. elegans) has been used as a powerful terrestrial model organism for environmental toxicity studies owing to its various advantages, including ease of culture, short lifespan, small size, transparent body, and well-characterized genome. In vivo bioassays and field studies can analyze and evaluate various toxic effects of the toxicants on the model organism, while emerging technologies allow profound insights into molecular disturbances underlying the observed phenotypes. In this review, we discuss the applications of C. elegans as a model organism in environmental toxicity studies and delineate apical assays such as lifespan, growth rate, reproduction, and locomotion, which are widely used in toxicity evaluation. In addition to phenotype assays, a comprehensive understanding of the toxic mode of action and mechanism can be achieved through a highly sensitive multi-omics approach, including the expression levels of genes and endogenous metabolites. Recent studies on environmental toxicity using these approaches have been summarized. This review highlights
Who reads Caenorhabditis Elegans: a Model Organism in the Toxicity Assessment of Environmental Pollutants?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Nguyen Phuoc Long; Jong Seong Kang; Hyung Min Kim
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)