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Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles by Vivian E Saper; Michael J Ombrello; Adriana H Tremoulet; Gonzalo Montero-Martin; Sampath Prahalad; Scott Canna; Chisato Shimizu; Gail Deutsch; Serena Y Tan; Elaine F Remmers; Dimitri Monos; Timothy Hahn; Omkar K Phadke; Elaine Cassidy; Ian Ferguson; Vamsee Mallajosyula; Jianpeng Xu; Jaime S Rosa Duque; Gilbert T Chua; Debopam Ghosh; Ann Marie Szymanski; Danielle Rubin; Jane C Burns; Lu Tian; Marcelo A Fernandez-Vina; Elizabeth D Mellins; Jill A Hollenbach; Drug Hypersensitivity Consortium is a Medicine article available to read on EtoBox.
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## Objectives Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, delayed hypersensitivity reaction (DHR). We observed DRESS to inhibitors of interleukin 1 (IL-1) or IL-6 in a small group of patients with Still’s disease with atypical lung disease. We sought to characterise features of patients with Still’s disease with DRESS compared with drug-tolerant Still’s controls. We analysed human leucocyte antigen (HLA) alleles for association to inhibitor-related DHR, including in a small Kawasaki disease (KD) cohort. ## Methods In a case/control study, we collected a multicentre series of patients with Still’s disease with features of inhibitor-related DRESS (n=66) and drug-tolerant Still’s controls (n=65). We retrospectively analysed clinical data from all Still’s subjects and typed 94/131 for HLA. European Still’s-DRESS cases were ancestry matched to International Childhood Arthritis Genetics Consortium paediatric Still’s cases (n=550) and compared for HLA allele frequencies. HLA association also was analysed using Still’s-DRESS cases (n=64) compared with drug-tolerant Still’s controls (n=30). KD subjects (n=19) were similarly studied. ## Results Still’s-DRESS fe
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- Author
- Vivian E Saper; Michael J Ombrello; Adriana H Tremoulet; Gonzalo Montero-Martin; Sampath Prahalad; Scott Canna; Chisato Shimizu; Gail Deutsch; Serena Y Tan; Elaine F Remmers; Dimitri Monos; Timothy Hahn; Omkar K Phadke; Elaine Cassidy; Ian Ferguson; Vamsee Mallajosyula; Jianpeng Xu; Jaime S Rosa Duque; Gilbert T Chua; Debopam Ghosh; Ann Marie Szymanski; Danielle Rubin; Jane C Burns; Lu Tian; Marcelo A Fernandez-Vina; Elizabeth D Mellins; Jill A Hollenbach; Drug Hypersensitivity Consortium
- Publisher
- BMJ
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)