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GastroPlus ACAT Model Evaluation in Drug Discovery by Theodora Seviani Amelia is a document available to read on EtoBox.

What is GastroPlus ACAT Model Evaluation in Drug Discovery about?

This study evaluates the GastroPlus Advanced Compartmental and Transit (ACAT) model for predicting oral exposure of 623 drug candidates during early drug discovery. The model demonstrated reasonable accuracy in predicting oral exposure for BCS class 1 compounds, while predictions for classes 2, 3, and 4 were less reliable. The findings suggest that refining the model with additional solubility and permeability data could enhance its predictive capabilities in drug development.

Author

Theodora Seviani Amelia

Language

EN